Anyone who may think they have seen Madeleine or has any information on her disappearance please contact:
Hope: One of the posters being released by the Find Madeleine Campaign
'Given the flavour of what came out in the Portuguese media at that time it was understandable; regrettable but understandable. 'But when you meet them, and get to know them, you realise quite quickly that they aren't making this up. And when Madeleine is recovered, a lot of people will regret what they wrote.' Sadly, I am not at all sure that she ever will be found. Flawed as the Portuguese police case against the McCanns clearly was, it is not so much the hard evidence that now convinces me that I was wrong, but our old friend gut instinct, which in my case has completely changed after following the case from a distance for many months. I have come to admire the McCanns for their cussed determination and refusal to alter course, despite all the criticism. When I spoke to Madeleine's two grandmothers this week, that admiration was cemented. 'The whole family are physically exhausted. Kate, in particular, is very tired after coming home from America,' her mother, Susan Healy, told me from her Liverpool home. 'She has had a hectic couple of weeks and really needs to recharge her batteries, but I don't think she has thought about stopping. Not for a minute. I don't think either of them can stop - that's the awful thing. 'They are just stuck in a situation where they don't have a lot of control. The only control they have is to remind people that Madeleine is still missing. That is why they do it. 'You have to understand that everything Kate does - everything - is done because she wants her daughter back. That's the only question they ever ask themselves: will this help us find Madeleine? Nothing else is of any importance. 'If Kate ever gets to the end of the line - I mean, if they got to the stage where they thought there was nothing more they could do - then that would be very difficult. But it would appear that they haven't reached that stage. 'Madeleine is their daughter and they've simply got to carry on. I don't know whether they would call it optimism or not, but they have to keep hoping. If they shrugged their shoulders and said "OK, she's not alive any more," they would be letting her down, wouldn't they?' In Glasgow, Mr McCann's mother, Eileen, told me much the same thing. 'There's nothing to say that Madeleine isn't alive, so why would they think otherwise?' she said. 'We never even discuss any other possibility.' You can only applaud such spirit. But if, against all the conceivable odds, Madeleine really has survived, what has become of her? This week, in a TV reconstruction of her abduction, the latest private detectives to be hired by the McCanns - two experienced former CID men from the North of England, whose no-nonsense approach contrasts sharply with that of their expensive and unproductive predecessors - may uncover fresh clues. After sifting through reams of previously unexamined Portuguese judicial documents and reinterviewing key witnesses, there is talk of a new 'mystery man' apparently seen loitering near the apartment on that fateful Thursday night. The programme will not solve the most enduring and troubling missing person inquiry of modern times, of course. Nor will it silence the whispers from those who still harbour lingering doubts about Mr and Mrs McCann. Nevertheless, we can be sure that they will continue to carry their cross with stoicism.